Zhuangli reservoir is located in hydrogeological unit of Yangzhuang basin. Reservoir construction will change recharge, runoff discharge condition and the flow field of underground water. According to hydrogeological conditions and groundwater exploitation and utilization of Yangzhuang basin, by using the Visual Madflow4.1 software, groundwater flow model has been established. By simulating the influence of Yangzhuang reservoir after the completion to groundwater levels and flow field, relative countermeasures are put forward for groundwater source protection.